Effect of Zhongfengkang on the Expression of AQP-4mRNA in Brain of Focal Cerebral Ischemia Rats / 中药新药与临床药理
Traditional Chinese Drug Research & Clinical Pharmacology
;
(6)2000.
Article
in Chinese
| WPRIM
| ID: wpr-574492
ABSTRACT
Objective To observe the effect of Zhongfengkang on the expression of Aquaporin 4 mRNA(AQP-4mRNA) in brain of focal cerebral ischemia rats. Methods The rat model of focal cerebral ischemia was established by inserting nylon thread.The dynamic changes of AQP-4 mRNA expression in the model group at 12th,24th,48th,72nd and 96th hour after cerebral ischemia were examined and the effect of Zhongfengkang on AQP-4 mRNA expression and cerebral edema at 48 th hour after cerebral ischemia was observed.Results At 12th hour after cerebral ischemia,the expression of AQP-4mRNA in the model group increased compared with the sham-operation group,and it arrived to the peak at 72th hour(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Traditional Chinese Drug Research & Clinical Pharmacology
Year:
2000
Type:
Article
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