Your browser doesn't support javascript.
loading
Effects of Neutralization by Soluble ABH Antigens Produced by Transplanted Kidneys From ABO-Incompatible Secretor Donors
Annals of Laboratory Medicine ; : 254-260, 2017.
Article in English | WPRIM | ID: wpr-57450
ABSTRACT

BACKGROUND:

Grafts survive despite blood group antigens on the transplant being continuously exposed to antibodies in the blood of recipients in ABO-incompatible kidney transplantation (ABOi KT), owing to the mechanism of accommodation. We analyzed the immunodynamics of soluble ABH antigens in allografts from secretor donors and the influence of such immunodynamics on accommodation and subsequent graft survival in ABOi KT.

METHODS:

The genotype of a known human β-galactoside α-1,2-fucosyltransferase gene (FUT2), which determines soluble ABH antigen secretor status, was established in 32 donors for ABOi KT at the Severance Hospital, from June 2010 to July 2015. Clinical outcomes of recipients, such as anti-A/B antibody titer change, renal function, and graft survival, were evaluated.

RESULTS:

Twenty-five donors were secretors (78.1%), and seven were nonsecretors (21.9%). The frequency of anti-A/B IgG or IgM antibody titer elevation or reduction post-transplantation was not significantly related to donor secretor status. However, IgM titer was rapidly reduced in recipients transplanted from nonsecretor donors (P=0.01), which could be explained by the lack of absorption effect of soluble antigens, enhancing the binding of antibodies to antigens in the allografts. Interestingly, soluble ABH antigens did not affect rejection-free graft survival, which may be due to the nature of β-galactoside α-1,2-fucosyltransferase.

CONCLUSIONS:

Soluble ABH antigens produced by transplanted kidneys from secretor donors played a role in inducing accommodation within three months of KT through neutralization; however, major graft outcomes were not affected.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Tissue Donors / Blood Group Incompatibility / Blood Group Antigens / Immunoglobulin G / Immunoglobulin M / Kidney Transplantation / Transplants / Absorption / Allografts / Genotype Limits: Humans Language: English Journal: Annals of Laboratory Medicine Year: 2017 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Tissue Donors / Blood Group Incompatibility / Blood Group Antigens / Immunoglobulin G / Immunoglobulin M / Kidney Transplantation / Transplants / Absorption / Allografts / Genotype Limits: Humans Language: English Journal: Annals of Laboratory Medicine Year: 2017 Type: Article