Your browser doesn't support javascript.
loading
Novel 11-deoxylglycyrrhetinic acid-30-acylamide derivatives / 中草药
Zhongcaoyao ; Zhongcaoyao;(24)1994.
Article in Zh | WPRIM | ID: wpr-574561
Responsible library: WPRO
ABSTRACT
Objective To synthesize the novel derivatives of 11-deoxyl glycyrrhetinic acid with high anti-inflammatory activities.Methods 11-Deoxylglycyrrhetinic acid was obtained by deoxidizing glycyrrhetinic acid with Zn(Hg)/HCl,and then a series of 11-deoxylglycyrrhetinic acid 30 acylamide derivatives were synthesized by coupling with R-Ar-isoxazole-methylamine.And the synthesized compounds were confirmed by the methods of IR,(()~1H-NMR),(()~(13)C-NMR),and MS.Two models were used to evaluate the preliminary anti-inflammatory activity of the compounds.Results The structures of all the new compound were identified by the spectra of IR,(()~1H-NMR),(()~(13)C-NMR),and MS.The compound 1,3,5 and 7 were proven to have a significant anti-inflammatory activity.Conclusion Some 30-acylamide derivatives of glycyrrhetinic acid have significant anti-inflammatory activities.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: Zhongcaoyao Year: 1994 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Zhongcaoyao Year: 1994 Type: Article