Novel 11-deoxylglycyrrhetinic acid-30-acylamide derivatives / 中草药
Zhongcaoyao
; Zhongcaoyao;(24)1994.
Article
in Zh
| WPRIM
| ID: wpr-574561
Responsible library:
WPRO
ABSTRACT
Objective To synthesize the novel derivatives of 11-deoxyl glycyrrhetinic acid with high anti-inflammatory activities.Methods 11-Deoxylglycyrrhetinic acid was obtained by deoxidizing glycyrrhetinic acid with Zn(Hg)/HCl,and then a series of 11-deoxylglycyrrhetinic acid 30 acylamide derivatives were synthesized by coupling with R-Ar-isoxazole-methylamine.And the synthesized compounds were confirmed by the methods of IR,(()~1H-NMR),(()~(13)C-NMR),and MS.Two models were used to evaluate the preliminary anti-inflammatory activity of the compounds.Results The structures of all the new compound were identified by the spectra of IR,(()~1H-NMR),(()~(13)C-NMR),and MS.The compound 1,3,5 and 7 were proven to have a significant anti-inflammatory activity.Conclusion Some 30-acylamide derivatives of glycyrrhetinic acid have significant anti-inflammatory activities.
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Language:
Zh
Journal:
Zhongcaoyao
Year:
1994
Type:
Article