Polymorphic gene regulation of UDP-glucuronosyltransferase 1A in human colorectal epithelium and liver / 中华消化杂志
Chinese Journal of Digestion
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-574752
ABSTRACT
Objective To analyze tissue-specific expression and polymorphic regulation of the UDP - glucuronosyltransferase (UGT) 1A gene in human tissue. Methods Forty colorectal cancer tissue. 20 normal colorectal tissue and 10 normal liver tissue were studied. UGT 1A transcriptions were investigated by exon-1 specific RT-PCR. UGT 1A proteins were studied using Western blotting analysis. Meanwhile catalytic activity of microsomes was evaluated using N-hydroxy-PhiP. Results (1) UGT 1A mRNA expressions were found to be significantly down-regulated in colorectal cancer tissue as compared with the surrounding normal tissues(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Digestion
Year:
2001
Type:
Article
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