The experimental studies of Chinese herbs as a vascular embolization agent for the hepatic arteries / 介入放射学杂志

ABSTRACT

Objective To study the efficacy,safety and correlative characteristics of Chinese herb as a vascular embolization agent.Methods Vascular embolization agent combined from several kinds of Chinese herb was manufactured and served as anticarcinogen and coagulant according to the chinese Pharmacopeia.The characteristics of the combination embolization agent through embolizing the hepatic arteries in eight pigs were studied. Results The combination agent was a non-homogenous suspension,easily to be injected through 5-F catheter with hyper attenuation under fluoroscopy;simultaneously with good histocompatibility and hemo-compatibility and without feverish response and toxicity.The combination agent mainly embolized the peripheral arteries with maintaining occlusion for 5 weeks and without formation of collateral circulation.Slight injuries of normal hepatic tissues with hepatic cytonecrosis and endochyloma focal necrosis were found through optical and electronic microscopy.Conclusions The Chinese herb combination agent is safe and effective in experimental application with good angioembolic function and a potential peripheral embolization agent.