Expression of survivin in bladder transitional cell cancer and its relationship with proliferation of cancer cells and recurrence of cancer / 重庆医科大学学报

ABSTRACT

Objective: To study the expression of a novel inhibitor gene of apoptosis,survivin,in bladder transitional cell cancer,and its relationship with the expression of ki67 genes and recurence of bladder cancer.Methods: Using streptavidin-biotin peroxidase(SP) method,we examined the expression of survivin and ki67 proteins in 10 normal bladder tissues and 58 bladder transitional cell cancer tissues and followed up all of the cases,the time of follow-up survey was 11 to 48 months,with the average of 29 months.Results: Survivin was expressed in 41 out of 58(70.7%) cases of BTCC.In contrast,normal bladder epithelium did not express survivin.Overexpression of survivin was related to the tumor grade and clinical stage.The expression of survivin were strongly corelated with ki67 expression.The recurrence time of grade Ⅰ-Ⅱ bladder cancer in which expression of survivin was positive was 11?9 months,while the recurrence time was 29?15 months for negative expression of survivin in the of bladder cancer.Conclusion: Apoptosis inhibition gene survivin may participate in the onset and progression of bladder transitional cell cancer.High expression of survivin is correlated with hyperplasia and recurrence of bladder tranditional cell cancer.