The Study on the Effects of the Components of Mongolian Milkvetch Root and Red Sage Root Compound on the Expression of Matricial Metal Protease-9 (MMP-9) mRNA on Placental Nourish Cells and the Blood Plasma Level of IL-10 in Model Pregnant Rats / 中国中医药信息杂志

ABSTRACT

Objective To explore the molecular mechanism of elevating placental blood supply by the component from Mongolian Milkurtch and red sage Root. Method Abstract the effective components from Mongolian Milkurtch and red sage Root, apply L-Arginine methy1 ester (L-NAME) to make NO production blocking model, use ELISA to check IL-10 in plasma of 18 d pragant rats, and FISH to check the expression of matricial metal protease-9 (MMP-9) mRNA. Results The plasma level of IL-10 of model group was lower than that of blank group (P 0.05). Conclusion By interving the relationship between IL-10 and MMP-9, the components of Mongolian milkvetch root and red sage root compound may affect the shift and invadation of deciduas, so as to prevent fleet embedding, help building the circulation between mother and embryo, and keep the placental blood supply.