Analysis on Center Effect in Correlation between the Scores of Qi-Yin Deficiency Syndrome and Blood Sugar Level in Patients with Diabetes / 中药新药与临床药理

ABSTRACT

Objective To analyze the center effect in correlation between the scores of Qi-Yin deficiency syndrome(SQYD)and blood sugar level in diabetes. Methods Correlation, consistency reliability and distinguish ability analysis were used to evaluate the correlation of the scores of Qi-Yin deficiency syndrome and blood sugar level according to the data from a clinical trial in phase Ⅲon the diabetes. Results There was a significant correlation between fasting blood sugar (FPG)level and 2-hour blood sugar (2 hPG)level at baseline, treatment end point and difference before and after treatment, and the variation of this correlation was slight (CV=0.1～0.258).But there was a insignificant correlation among SQYD and FPG or 2hPG, and the variation of this correlation was obvious (CV=0.560～2.559).The correlation coefficient among SQYD and FPG fluctuated in the range of -0.096～0.611,and that among SQYD and 2hPG in the range of -0.150～0.537. Roughly the variation of correlation among SQYD and FPG or 2hPG was 5～10 times greater than that of between FPG and 2hPG. Conclusion There exists an obvious center effect in correlation between the scores of Qi-Yin deficiency syndrome and blood sugar level in diabetes.