Therapeutic potential of madecassoside in transgenic mice of amyotrophic lateral sclerosis / 中草药
Chinese Traditional and Herbal Drugs
;
(24)1994.
Article
in Chinese
| WPRIM
| ID: wpr-575129
ABSTRACT
Objective To investigate the therapeutic potential of madecassoside in mice expressing a mutant human Cu,Zn superoxide dismutase(SOD1)-G93A linked to human amyotrophic lateral sclerosis(ALS).Methods Effects of madecassoside on onset of clinical disease,survival of mice,decline of motor function,and motor neuron(MN) degeneration were observed by behavioral analysis and histological eva-(luation.) Results Madecassoside(61.1?11.0) and(185.6?18.7) mg/(kg?d) ig administration,beginning at 70 d of age until death,prolonged survival of SOD1-G93A ALS mice by 11.4 and 9.4 d,respectively(P
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
1994
Type:
Article
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