Advances in research on target-oriented drug delivery system of Chinese materia medica / 中草药

ABSTRACT

Target-oriented drug delivery systems(TODDS) of Chinese materia medicia(CMM) is ascribed as preparations in which active fractions or single ingredient extracted from CMM or natural medicines are directly delivered with the help of different carriers to target organs,target tissues,and target cells or intracellula.Recent advances of research on TODDSs of CMM classified according to carriers,such as liposomes,microspheres,nanocapsules,and emulsions are reviewed.In addition,due to the specific actions of CMM on intestinal diseases,oral colon targeting drug delivery system is considered substantials for TODDSs of CMM.Domestic researches on TODDS of CMM in its initial stage are limited to formulations using single natural active ingredient as raw material.While the fewer TODDSs using CMM active fractions or formula recipes are underway,which relates to the tremendous difficulties in both establishment of quality standard for CMM active fractions and technology for preparation of CMM.Nevertheless one of the important goals for the development on preparation of CMM is TODDS.