Effect of Xiaoerkechuanning Granule on Allergic Asthma in Guinea Pigs / 中国中医药信息杂志

ABSTRACT

Objective To study the antiasthmatic effect of Xiaoerkechuanning Granule (KCN) in guinea pigs with allergic asthma. Method The allergic asthma model in guinea pigs was induced by ovalbumin (OVA), and detemine the incubation period of asthma, the content of malondiadehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) in blood serum, histopathologic changes of lungs. Results The KCN can markedly prolong the incubatin period, increase the activities of SOD, alleviate the histopathologic changes. Conclusion KCN has obviously protective effects on experimental allergic asthma in guinea pigs.