The Analysis of Methylenetetrahydrofolate Reductase Mutation in Recurrent Spontaneous Abortion Associated with Hyperhomocysteinemia / 대한불임학회지
Korean Journal of Fertility and Sterility
;
: 441-446, 1999.
Article
in Korean
| WPRIM
| ID: wpr-57533
ABSTRACT
OBJECTIVE:
To analyze the methylenetetrahydrofolate reductase (MTHFR) mutation in recurrent spontaneous abortion associated with hyperhomocysteinemia. MATERIAL ANDMETHOD:
The blood Sample of habitual aborter with high fasting homocysteine level was tested by PCR-RFLP method.RESULTS:
The patient was found to be a homozygosity for MTHFR gene mutation that was confirmed by the finding which is consistent with the mutation at the nucleotide 677 C to T, Corresponding to Ala to Val.CONCLUSIONS:
Hyperhomocysteinemia due to MTHFR mutation is a cause of recurrent spontaneous abortion. Therefore, the MTHFR mutation should be examined in the workup of recurrent spontaneous abortion showing hyperhomocysteinemia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Abortion, Spontaneous
/
Fasting
/
Hyperhomocysteinemia
/
Methylenetetrahydrofolate Reductase (NADPH2)
/
Homocysteine
Limits:
Female
/
Humans
/
Pregnancy
Language:
Korean
Journal:
Korean Journal of Fertility and Sterility
Year:
1999
Type:
Article
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