Pharmacokinetics of lyophilization of toad venom-loaded solid lipid nanoparticles / 中成药
Chinese Traditional Patent Medicine
;
(12)1992.
Article
in Chinese
| WPRIM
| ID: wpr-575410
ABSTRACT
AIM:
To investigate the pbarmacokinetics of lyophilization of toad venom(Venenum Bufouis)-loaded solid lipid nanoparticles(Vs-SLN).METHODS:
Cinobufagin and resibufogenin plasma concentration in rat was determined by RP-HPLC.RESULTS:
Statistic test showed that there was significant difference between lyophilization of Vs-SLN and Vs-injection for C_(max)、 AUC_(extra)、 MRT.CONCLUSION:
As the circulating time of the drug in blood was markedly prolonged,Vs-SLN can be developed to a novel preparation for controlled release of lipophilic drugs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional Patent Medicine
Year:
1992
Type:
Article
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