The relation between expression of MMP-9/TIMP-1 in the implantation window phase of endometrium and estrodial and progesteron / 重庆医科大学学报

ABSTRACT

Objective: To study the relation between the expression of matrix metalloproteinase-9(MMP-9) / tissue inhibitor of metalloproteinase-1(TIMP-1) protein in the implantation window endometrium phase and serum estradiol and progesterone.Methods: 31 women with regular ovulation were included to obtain endometrium samples in implantation window phase,and at the same time serum were abstracted from vein for E2 and P testing.Immunohistochemical analysis was applied to measure the expression of MMP-9/TIMP-1 protein in the implantation window.Analysis the correlationship between MMP-9/TIMP-1 and E2 and P.Results: The light dense of the expression of MMP-9 / TIMP-1 protein in the endometrium of implantation window were 0.163?0.025,0.143?0.015 respectively,and the corresponding serum E2,P were 182.153?45.774pg/ml,22.997?6.697ng/ml respectively.There was negative correlationship between MMP-9 and P(P