Serum Sclerostin Levels in Patients with Human Immunodeficiency Virus Infection and Their Association with Bone Turnover Markers and Bone Mineral Densitometry
Journal of Bone Metabolism
;
: 16-22, 2016.
Article
in English
| WPRIM
| ID: wpr-57550
ABSTRACT
BACKGROUND:
The aim of the study was to compare serum sclerostin levels in human im-munodeficiency virus (HIV)-infected patients and healthy controls, and to evaluate their relationship with bone turnover markers (BTM) and bone mineral density (BMD).METHODS:
We prospectively studied 33 HIV treatment-naive patients and 63 healthy individuals; matched for age and sex. Serum sclerostin levels, BTM, BMD were measured. Viral load and cluster of differentiation 4 (CD4) levels were also assessed in HIV-infected patients.RESULTS:
The mean+/-standard deviation (SD) age of sample was 37.6+/-10.3 years (range, 19 to 59 years). Of the 96 subjects, 58 (60.4%) were male and 38 (39.6%) were female. Infection with HIV is associated with significant reduction in serum sclerostin levels (HIV-infected 39.4+/-28.3 vs. non HIV 76.6+/-15.7 pmol/L; P0.05).CONCLUSIONS:
These findings suggest that untreated HIV and the resulting immune deficiency and/or systemic inflammation could be an important regulator of serum sclerostin in this population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoporosis
/
Saudi Arabia
/
Spine
/
Glycoproteins
/
Bone Density
/
Prospective Studies
/
HIV
/
Viral Load
/
Densitometry
/
Femur Neck
Type of study:
Observational study
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Bone Metabolism
Year:
2016
Type:
Article
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