Effects of Gross Saponins of Tribulus on Na~+-K~+-ATPase and Ca~(2+)-Mg~(2+)-ATPase Activity and Lactic Acid Content in Hyperlipemic Rats with Acute Myocardial Infarction / 中药新药与临床药理

ABSTRACT

Objective To observe the effects of Gross Saponins of Tribulus terrestris(GSTT)on energy metabolism and lactic acid metabolism in hyperlipemic rats with acute myocardial infarction(AMI).Methods Rats were fed with high fat diet for 15 days to induce hyperlipidemia,then left anterior descending branch of coronary artery of rats were ligated.Rats showed ST segment elevation in lead Ⅱof electrocardiogram were proved to be AMI rats.AMI rats with hyperlipidemia were divided randomly into five groups(normal group,model group,24.3 mg?kg-1 GSTT group,12.15 mg?kg-1 GSTT group,Simvastatin group)and test drugs were given in succession for 28 days.Left ventricular ischemic myocardium were harvested to prepare myocardial mitochondria.Na+-K+-ATPase and Ca2+-Mg2+-ATPase activity and lactic acid content were measured.Results Compared with the normal group,Na+-K+-ATPase and Ca2+-Mg2+-ATPase activity significantly lowered in model group(P