A clinical study of massage combined with hyperbaric oxygen in rehabilitation of moderate or severe hypoxic ischemic encephalophy / 重庆医科大学学报

ABSTRACT

Objective: To observe the clinical effect of massage combined with Hyperbaric Oxygen(HBO) on improving the intelligence of infants with moderate or severe Hypoxic Ischemic Encephalophy(HIE).Methods: 122 newborns aged less than 2 days were randomly divided into four groups.33 cases in the control group were treated with cerebrolysin,29 cases in the second group were treated with cerebrolysin and massage,32 cases in the third group were treated with cerebrolysin and HBO,and 28 cases in the fourth group with cerebrolysin,HBO and massage.The mental development index(MDI) and the psychomotor developmental index(PDI) were observed when they were 3?6?9?12 and 18 months old.Results: The MDI and PDI of infants with moderate HIE was significantly higher in the fourth group than those in the control group(P0.05),and no higher in the control group as well.The MDI and PDI were in mental retardation after 18 months' treatment,mostly accompanied by cerebral palsy which were higher in the fourth group than those in the control group,and grew higher with time,and can be in borderline after 18 months' treatment.There was statistically significant difference between them(P