Influence of Temperature and Perfusate Modifier on In-vitro Mass Transfer Coefficient of Microdialysis with Sinomenine as a Model Drug / 广州中医药大学学报
Journal of Guangzhou University of Traditional Chinese Medicine
;
(6)2000.
Article
in Chinese
| WPRIM
| ID: wpr-575727
ABSTRACT
【Objective】To observe the influence of temperature and perfusate modifier on in-vitro mass transfer coefficient of microdialysis with sinomenine as a model drug.【Methods】The in-vitro relative recovery(RR) was assayed by HPLC at different temperatures and in perfusate including different concentrations of alcohol,and then the mass transfer coefficient was calculated.【Results】In-vitro RR increased with the temperature and the concentrations of alcohol,so did the mass transfer coefficient.【Conclusion】Temperature and alcohol at different concentrations have an effect on RR and mass transfer coefficient of microdialysis with sinomenine as a model drug.
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Guangzhou University of Traditional Chinese Medicine
Year:
2000
Type:
Article
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