Effects of Heat-clearing,Dampness-resolving and Stasis-removing Therapy on Aortic Ultrastructure of Rabbits with Atherosclerosis / 广州中医药大学学报

ABSTRACT

【Objective】To explore the relationship between damp-heat syndrome(DHS)and aortic atheroslerosis(AA),and to observe the effect of heat-clearing,dampness-resolving and stasis-removing therapy on AA.【Methods】DHS rabbit models were established by feeding with fatty diet and intravenous injection of endotoxins.The development of AA were observed under light microscope and electron microscope to evaluate the effect of heat-clearing,dampnessresolving and stasis-removing therapy.【Results】 Compared with the blank control group,an obvious atherosclerotic changes were showed in the model rabbits injury of arterial intima,appearance of atherosclerotic plaque,formation of foam cells and proliferation of smooth muscle cells.After treatment,the above damages were relieved.【Conclusion】There has histological evidence for the pathogenesis of internal retention of damp-heat causing blood stasis,and heat-clearing,dampness-resolving and stasis-removing therapy is effective for AA.