Expression and clinical value of FLIP,FADD in carcinoma of larynx / 重庆医科大学学报

ABSTRACT

Objective:To study the expression of apoptosis related gene FLIP and FADD in 56 cases of human laryngeal squamous cell carcinoma.Methods:Immunohistochemical method(SP) was used to detect the expressions of FLIP and FADD in larynx carcinoma.PCNA was detected to evaluate the proliferation of carcinoma cell.Results:FLIP expression showed a positive correlation with the proliferation of larynx carcinoma cells.FADD displayed a reverse results.No associations were observed in the expressions of FLIP and FADD.The expressions of FLIP and FADD were related to tumor's clinical stage,pathological grade,but not to age,sex of patients and lymphatic metastasis.Conclusions:The abnormal expressions of FLIP and FADD may play an important role in the development of larynx carcinoma.