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Effect of Dan Zhi Xiaoyao San and Its Extracts on Hypothalamus-Pituitary Gland-Adrenal Gland Secretion in Rats with Chronic Psychological Stress / 广州中医药大学学报
Journal of Guangzhou University of Traditional Chinese Medicine ; (6)2004.
Article in Chinese | WPRIM | ID: wpr-575956
ABSTRACT
【Objective】To investigate the effects of Dan Zhi Xiaoyao San(DZXS) and its extracts on hypothalamic corticotropin releasing hormone(CRH) and plasma corticosterone(CORT) in rats with chronic psychological stress.【MethodsWistar rats were randomized into 6 groups A(normal control),B(model control),C (extract of DZXS extracted by water extraction and alcohol precipitation,3.608?g/kg),D(extract of DZXS extracted by petroleum ether,0.087?g/kg),E(extract of DZXS extracted by polysaccharide,2.20?g/kg) and F(DZXS 14.4?g/kg).Except group A,the rat models of chronic multi-phase psychological stress were established in other groups by improved Cart method.Groups A and B were given normal saline,and groups C,D and E were given the corresponding drugs according to the experimental design.Hypothalamic CRH and plasma CORT contents were examined to explore the therapeutic mechanism.【Results】Compared with group A,hypothalamic CRH and plasma CORT contents were increased in group B;hypothalamic CRH content was decreased in groups C,E and F(P

Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial Language: Chinese Journal: Journal of Guangzhou University of Traditional Chinese Medicine Year: 2004 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial Language: Chinese Journal: Journal of Guangzhou University of Traditional Chinese Medicine Year: 2004 Type: Article