The effect of hyaluronic acid on anti-inflammatory action in mouse
Journal of the Korean Association of Oral and Maxillofacial Surgeons
;
: 16-22, 2010.
Article
in Korean
| WPRIM
| ID: wpr-57599
ABSTRACT
PURPOSE:
The purpose of this study was not only to evaluate the relative mRNA expression of interleukin-1beta(IL-1beta), cyclooxygenase2 (COX-2) and prostaglandin E2 (PGE2) by RT-PCR analysis but to observe pattern of edema by light microscopic and electron microscope after topical apply of hyaluronic acid in inflammation-guided mouse. MATERIAL ANDMETHODS:
Mice of this study were devided into 4 groups Control group (no inflammation guided), Positive control (inflammation guided + vaselin apply), Protopic group (inflammation guided + protopic apply), Hyaluronic group (inflammation guided + hyaluronic acid apply).RESULTS:
Hyaluronic group showed less expressions of IL-1beta, COX-2, PGE2 than those of positive control & protopic group. Hyaluronic group revealed a decreased inflammation than positive control & protopic group in Light Microscope. Hyaluronic group appeared decreased edema of ear compare to positive control & protopic group in Elecron Microscope.CONCLUSION:
It was considered that hyaluronic acid has an antiinflammatory effect for intercepting the gene expression of cytokines related to inflammation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA, Messenger
/
Dinoprostone
/
Gene Expression
/
Cytokines
/
Ear
/
Edema
/
Electrons
/
Hyaluronic Acid
/
Inflammation
/
Light
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Year:
2010
Type:
Article
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