Formula and process optimization of Danggui Buxue Pellets prepared by extrusion-spheronization / 中成药

ABSTRACT

AIM: To prepare traditional Chinese medicine formula Danggui Buxue Pellets by extrusion-spheronization and to study the optimal process and formulation. METHODS: Danggui Buxue Pellets were prepared by a new style extrusion-spheronization equipment;The optimal process and formulation were obtained on the studies of influenitial factors and L_9(3~4) orthogonal design,The micromeritic properties and reception percentage of pellets were determined. RESULTS: The prepared Danggui Buxue Pellets by extrusion-spheronization were all spheral with smooth surface;The percent of reception was not less than 85%. CONCLUSIONS: Extrusion-spheronization is suitable to produce herbal medicine pellets.The preparation process is simple and feasible;The quality of the prepared pellets is excellent and the percent of reception is high.