Influence of Shoucong Capsule on Total Autioxidative Capacity,Lipofuscin and Brain Tissue Pathological Changes in Alzheimer's Disease Rats / 中国中医药信息杂志

ABSTRACT

Objective To study the mechanism of Shoucong to prevent and cure Alzheimer's disease by observing the effect of shoucong capsule on total autioxidative capacity (TAOC), Lipofuscin (LIP) in AD rat brain tissue and blood, and brain tissue pathological changes. Methods Male wistar rats were randomly divided into 5 groupblank compared group, model compared group, Naofukang group, Shoucong Capsule (low, high dose) group. AD compound model rats were made by injected with D-galactose on the neck of rats, then injected with scopolamine in the intraperiton of rats. They were prevented and cured with Shoucong Capsule. TAOC, LIP level in rat brain tissue and blood were examined with spectroscopic analysis, brain tissue pathological changes were observed under light microscope. Results Compared with AD model group, Shoucong Capsule enhanced TAOC level in rat brain tissue and blood, deceased LIP level in rat brain tissue, and lessened the pathological injury of dementia rats. Conclusions Enhancing TAOC level and deceasing LIP level in brain tissue and blood may be one of the mechanism for Shoucong Capsule to prevent and cure Alzheimer's disease.