Effects of Psoralen on Improving Chemotherapeutics Drug’s Concentration of HL60 Cells / 航天医学与医学工程
Space Medicine & Medical Engineering
;
(6)2006.
Article
in Chinese
| WPRIM
| ID: wpr-576114
ABSTRACT
Objective To determine the reversal effect of psoralen on multidrug resistance (MDR) in the harringtonine (HT)-resistant leukemic cell line HL60/HT. Method The modulating effect of psoralen on MDR in HL60 and HL60/HT cells were determined by the measurement of cell growth and viability via MTT assay. High performance liquid chromatography(HPLC) was used to analyze intracellular HT concentrations in HL60/HT and HL60 cells treated with psoralen. Result Psoralen from 1 to 20 ?mol/L could reduce the value of IC_ 50 to HT and enhance the accumulation of HT in HL60/HT cells. Conclusion Psoralen can reverse MDR of HL60/HT cells and is a potential modulator of MDR.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Space Medicine & Medical Engineering
Year:
2006
Type:
Article
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