Irirotecan Combined with Fluoropyrimidine in the Treatment of 46 Cases with Metastatic Colorectal Carcinoma / 药物流行病学杂志
Chinese Journal of Pharmacoepidemiology
;
(4)2006.
Article
in Chinese
| WPRIM
| ID: wpr-576349
ABSTRACT
Objective:
To evaluate the efficacy and toxicity of Irirotecan(CPT-11) combined with 5-FU/CF in the treatment of metastatic colorectal cancer, in which FOLFOX4 or LV5FU2 had failed to cure it.Method:
46 cases of metastatic colorectal cancer patients were treated by CPT-11 combined with 5-FU/CF for one cycle every two weeks; namely, CPT-11 was given by 180mg/m2 iv d1, CF by 200mg/m2 iv d1-2, 5-FU by 400mg iv bolus d1, and 5-FU by 600mg/m2 iv 22h d1-2. Two weeks was a cycle. The study term was 3-6 months.Result:
CR was 0, PR was 39. 13% (18/46) , SD was 43.47% (20/46) , PD was 17.39% (8/46) and CBR was 82.69% (38/46). The clinical reaction evaluation efficiency was 78. 86% (36/46). Their life quality was notably improved.Conclusion:
CPT-11 combined 5-Fu/CF can be used as second-line treatment for metastatic colotedal cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pharmacoepidemiology
Year:
2006
Type:
Article
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