Experimental study on pharmacodynamic action of resisting gastric ulcer of Yukuining Granules and its acute toxicity / 中成药

ABSTRACT

AIM: To explore Yukuining Granules(Endoconcha Sepiae,Rhizoma Corydalis,Radix Astragali praeparata cum melle,Radix Paeoniae Alba,Radix et Rhizoma Glycyrrhizae praeparata cum melle,etc) pharmacodynamic action of resisting gastric ulcer. METHODS: The rat's gastric ulcer models were induced by irritabal stimulus,pyloric ligation,acetic acid and ethanol-induced gastric mucosa injure,respectively.The ulcer was observed and the content of gastric juice,gastric acidity and pepsin were measured.Yukuining Granules pharmacodynamic action was also measured by observing its effect of alleviating pain on torsivesion malposition mice.The max dosage that mice could tolerate was recorded everyday. RESULTS: YKN Granules could significantly reduce the areas of ulcers,restrain gastric ulcer,promote gastric ulcer heal,reduce gastric juice volume,restrain gastric secretion and alleviate the pain induced by acetic acid in mice,The daily max tolerant dosage was equal to 288 times of clinical routine. CONCLUSION: YKN Granules have a marked anti-ulcerative effect and show the less side effect.