Investigation of lumbar peak bone mass of 1435 female adults in Chongqing area / 重庆医科大学学报

ABSTRACT

Objective:To investigate peak bone mass(PBM) of female adults in Chongqing area and PBM change of females' lumbar vertebrae with age,bodyweight, height and body mass index(BMI),to provide scientific basis for diagnosis and prevention of osteoporosis. Methods:There were 1435 female adults in Chongqing area randomly selected. The assessment of BMD in spine region was performed by NORLAND XR-46 dual-energy X-ray absorptiometer. BMD of lumbar spine with age-related changes was fitted in the whole healthy women population by eight kinds of regression models. Best model equations of fitting were found and the reference databases of BMD in women were established.Group aged from 20 to 50(n=631)was PBM research group. Results:The PBM of the second,third and total lumbar vertebrae occurred in the group aged from 34 to 35,while that of the forth lumbar vertebrae occurred during 26 to 27 and reduction began at the age of 28. BMD would gradually decrease with the advancing of age when it achieved PBM. R square of cubic regression curve was maximum. The research showed height?body weight and BMI could influence PBM values of lumbar vertebrae. The effect of body weight was the most significant among these influential factors. Conclusions:The PBM level of female adults in Chongqing area was lower than that of other related research results in domestic,and the age of PBM was earlier than that of the others. A cubic regression model was the better model to establish a normal BMD reference curve. Proper nutrition and suitable figure keeping could result in higher PBM value in human life.