Rifaximin in treatment of acute bacterial diarrhea.a randomized,single-blind clinical trial / 重庆医科大学学报
Journal of Chongqing Medical University
;
(12)2003.
Article
in Chinese
| WPRIM
| ID: wpr-576678
ABSTRACT
Objective:
To evaluate the efficacy and safety of rifaximin against acute bacterial diarrhea.Methods:
The effect of rifaximin for the treatment of acute bacterial diarrhea was investigated in a randomized,single-blind clinical trial with control of ciprofloxacin.Patients were administered with rifaximin 0.4g tid on the first day,followed by 0.4g bid;as for ciprofloxacin 0.25g tid on the first day,followed by 0.25g bid,until the end of 3~7days treatment,respectively.Stool,blood(hepatic and renal functions),urine samples and ECG of pre-and post-treatment were assayed for safety evaluation of rifaximin in diarrhea patients.Results:
29 patients in rifaximin group and 25 in ciprofloxacin group showed similar efficacy rates and recovery rates, 100% and 91.3% respectively.There was no statistic difference between the two groups related to the effectiveness.The bacterium positive rate was 64.8%(35/54)before treatment.Bacterial clearance rates were 100% and 87.5%.No statistic difference and obvious side effect in the two groups were observed.Conclusion:
rifaximin is safe and effective in the treatment of acute bacterial diarrhea.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
Journal of Chongqing Medical University
Year:
2003
Type:
Article
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