Propofol Infusion Associated Metabolic Acidosis in Patients Undergoing Neurosurgical Anesthesia: A Retrospective Study
Journal of Korean Neurosurgical Society
;
: 135-140, 2014.
Article
in English
| WPRIM
| ID: wpr-57670
ABSTRACT
OBJECTIVE:
Propofol and volatile anesthesia have been associated with metabolic acidosis induced by increased lactate. This study was designed to evaluate changes in pH, base excess (BE), and lactate in response to different anesthetic agents and to characterize propofol infusion-associated lactic acidosis.METHODS:
The medical records of patients undergoing neurosurgical anesthesia between January 2005 and September 2012 were examined. Patients were divided into 2 groups those who received propofol (total intravenous anesthesia, TIVA) and those who received sevoflurane (balanced inhalation anesthesia, BIA) anesthesia. Propensity analysis was performed (1 1 match, n=47), and the characteristics of the patients who developed severe acidosis were recorded.RESULTS:
In the matched TIVA and BIA groups, the incidence of metabolic acidosis (11% vs. 13%, p=1) and base excess (p>0.05) were similar. All patients in the TIVA group who developed severe acidosis did so within 4 hours of the initiation of propofol infusion, and these patients improved when propofol was discontinued.CONCLUSIONS:
The incidence of metabolic acidosis was similar during neurosurgical anesthesia with propofol or sevoflurane. In addition, severe acidosis associated with propofol infusion appears to be reversible when propofol is discontinued.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Acidosis
/
Acidosis, Lactic
/
Propofol
/
Medical Records
/
Incidence
/
Retrospective Studies
/
Lactic Acid
/
Hydrogen-Ion Concentration
/
Anesthesia
/
Anesthesia, Inhalation
Type of study:
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Journal of Korean Neurosurgical Society
Year:
2014
Type:
Article
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