MODIFIED RECOMBINANT HUMAN aFGF PROTECTS TYROSINE HYDROXYLASE NEURONS IN SUBSTANTIA NIGRA OF PARKINSON DISEASE RATS FROM LOSS / 解剖学报
Acta Anatomica Sinica
;
(6)1955.
Article
in Chinese
| WPRIM
| ID: wpr-576771
ABSTRACT
Objective To observe the changes of rotation behavior and tyrosine hydroxylase immunopositive neurons and investigate how Mrh-aFGF affects them in substantia nigra of Parkinson disease rats. Methods After building a rat model of Parkinson disease by injecting 6-OHDA into substantia nigra and ventral tegmental area,we used Mrh-aFGF to intervene rats by lateral ventricle injection to observe how behavior of rats induced by apomorphine and tyrosine hydroxylase immunopositive neurons in substantia nigra of rats changes,then quantitatively analyzed the change of tyrosine hydroxylase immunopositive neurons. Results Rotation behavior was not found in control group,otherwise,actuation time was shorted,time length was prolonged,and average velocity of rotation was accelerated in Parkinson disease rats(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Acta Anatomica Sinica
Year:
1955
Type:
Article
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