The value of radionuclide imaging with ~(131)I-MIBG in diagnosis of adrenal medullary lesions / 重庆医科大学学报

ABSTRACT

Objective:To evaluate the clinical value of radionuclide imaging with ~(131)I-MIBG in the diagnosis of adrenal medullary lesions.Methods:The ~(131)I-MIBG adrenal medullary imaging results of 48 patients(12 with primary hypertension as control group,21 with pheochromocytoma,and 15 with adrenal medullary hyperplasia)were analyzed and compared with those of CT and B ultrasonography.The uptake ratio of adrenal gland to background and to myocardium were calculated and compared by ROI sequence.Results:In ~(131)I-MIBG imaging,for the patients with pheochromocytoma,11 of them were found abnormal radioac- tive increase of one adrenal gland;2 ectopic pheochromocytoma were demonstrated;3 were found with multiple abnormal ra- dioactive increase in the whole body besides adrenal gland were demonstrated with malignant pheochromoeytoma;one adrenal gland was shown clearly of 3 patients and 2 patients appeared negative,with the positive rate of 90.5%.Of the patients with adrenal medullary hyperplasia,8 were found with one adrenal gland imaging and 3 with two adrenal gland imaging;4 patients appeared with negative,with the positive rate of 73.3%.The uptake ratio(obtained by ROI sequence)in pheochromocytoma and hyperplasia group were remarkably higher than that in control group,of which pheochromocytoma group was remarkably higher than hyperplasia group.Conclusion:~(131)I-MIBG imaging is an effective tool in the localizing and qualitative diagnosis of adrenal medullary lesions.ROI sequence can increase the positive rate and benefit the differential diagnosis.