Effect of Liguistrazine on Neurotransmitter in Hyperkinesis Rats / 广州中医药大学学报

ABSTRACT

【Objective】To observe the effect of liguistrazine(Liz)on cerebral and serum monoamine neurotransmitter contents in spontaneous hypertension rats (SHR).【Methods】Twenty-four SHR rats were randomized into model group,hightdose Liz group(40 mg?kg-1?d-1),low-dose Liz group(20 mg?kg-1?d-1),and votalin group(4 mg?kg-1?d-1).The rats received gastric gavage of corresponding drugs according to the experimental design for 14 days.After treatment,the serum and hippocampal contents of dopamine,5-hydroxytryptamine and norepinephrine(NE)were detected with high performance liquid chromatography(HPLC).【Results】 High-and low-dose Liz markedly decreased cerebral NE content,increased serum and cerebral DA and 5-HT contents(P