Effect of Dahuang Mudan Decoction on Mice Colitis Induced by Trinitrobenzene Sulfonic Acid / 中药新药与临床药理

ABSTRACT

Objective To study the effect of Dahuang Mudan Decoction on experimental colitis induced by trinitrobenzene sulfonic acid(TNBS)in mice and to explore its mechanism.Methods Mice colitis model was established by rectal administration of trinitrobenzene sulfonic acid.Disease activity index(DAI)and histological scores were assessed,the serum level of TNF-? was detected by ELISA.Results Dahuang Mudan Decoction reduced DAI and histological scores in mice,and alleviate inflammation in colonic tissue.It also significantly decreased mice serum TNF-? level.Conclusions Dahuang Mudan Decoction shows positive therapeutic efficacy on mice colitis induced by trinitrobenzene sulfonic acid,and its mechanism may be involved in inhibiting the production of TNF-?.