Preparation and performance testing for super-paramagnetic contrast agent of magnetic resonance / 重庆医科大学学报

ABSTRACT

Objective:To explore the possibility as antisense gene carriers.Preparation of super paramagnetic iron oxide MR contrast agent Iron oxide nanoparticles and test their physical and Magnetic Properties.Methods:the iron oxide nanoparticles is obtained by means of Co-precipitation method,its structure is analyzed by X-ray powder diffraction method,its size and distribution is measured by transmission electron microscope,and its Susceptibility is measured by Vibrating Sample Magnetometer dollars.Results:Testing after dextran-coated particle diameter overall,the size is20～35nm,core diameter of around is 5nm,These particles possessed some characteristics of super paramagnetic.Relaxation rate Of the sample is 0.155?106/(mol?sec) and quality saturation magnetic intensity is 69.42162emu/g Fe.Conclusion:the sample possessed the advantages of small size,dispersed,super-paramagnetic,so it could be used as an anti-gene carriers.