Elementary investigaion of curative effects by DUXIL on cerebral dysfunction associated with disturbance of cerebral microcirculation / 重庆医科大学学报

ABSTRACT

Objective:To observe DUXIL's curative effects and mechanisms for cerebral ischemia and anoxia secondary to the alteration of altering the number and configuration of human erythrocyte,which results in cerebral microcirculatory disturbance and dysunction of cerebrum.Methods:The patients were divided into two groups randomly and each group had 20 patients who had the prodrome of cerebral ischemia and anoxia.One group took DUXIL and the other NIMODIPINE for 15 days for comparison.Blood test and CVA were performed separately before and after the treatment.Twenty patients were chosed randomly from each group for SPECT.Results:There are varging degrees increases of parameters of erythrocyte acompanyed by alteration of parameters of CVA before treatment and SPECT qualitative analysis shows areas of low perfusion with differents severities.The number and configuration of erythrocyte was changed in group taken DUXIL.The parameters of CVA had been improved and the defect of encephalic perfusion also amended.The clinical symptoms were alleviated or disappeared.But no improvement were obtained in the other group.Conclusion:DUXIL can improve symptoms of cerebral ischemia and anoxia by affecting erythrocyte to make it have more favourable erythrocyte deformability(ED),which can contribute to effective perfusion of cerebral microcirculation.