Effects of Total Rhizoma Panacis Japonica Saponins on Nitric Oxide Synthase of Hippocampus Region in the Mouse Repetitious Cerebral Ischemia Reperfusion and the Rat Focal Cerebral Ischemia / 中国中医药信息杂志

ABSTRACT

Objective To study the mechanism of protective effects of total rhizoma panacis japonica saponins(tRPJS)on the cerebral ischemia injury.Methods The middle cerebral artery occlusion model (MCAO)in rats and cerebral ischemia-reperfusion models in mice were used to investigate the influence of tRPJS on the nitric oxide synthase(NOS)and inducible nitric oxide synthase(iNOS)activity in hippocampus region.Results tRPJS significantly decreased the contents of NOS and iNOS in hippocampus region of MCAO rat and cerebral ischemia reinfusion mouse.Conclusion tRPJS has significantly protective effects by decreasing NOS and iNOS.