Effect of Artemisia capillaries Thunb on fatty liver rats with insulin resistance / 中成药

ABSTRACT

AIM: To study the liver protective hypolipidemic function of Artemisia capillaries Thunb on the fatty liver rats with insulin resistance of action. METHODS: Adult SD rats were maintained by high-fat-sugar-salt diet for 8 weeks,and extraction of Artemisia capillaries Thunb(high dosage 6.9 g/kg,low dosage 2.3 g/kg) was administered to the rats for 4 weeks by intragastric administration at the begining of 9~(th) week.And then all animals were killed and the blood was sampled to measure the levels of blood glucose,blood lipid(TC,TG,HDL-C,LDL-C,FFA),fasting serum insulin and the levels of MDA and TGF-?_1.The activities of ALT,AST and SOD also were measured.The liver was weighed and collected to observe the pathological changes. RESULTS: Compared with model rats,the levels of blood glucose and insulin decreased significantly in the treatment of Artemisia capillaries Thunb,and insulin sensitivity index returned to normal condition(P