Experimental research of Jiajian Yun? Decoction on ventricular remodeling / 中成药
Chinese Traditional Patent Medicine
;
(12)1992.
Article
in Chinese
| WPRIM
| ID: wpr-577647
ABSTRACT
AIM:
To explore the effects and mechanisms of classic prescription Jiajian Yun? Decoction(JJYND) on ventricular remodeling.METHODS:
Two kinds of ventricular remodeling model were induced by injecting L-thyroxine intraperitoneally or banding abdominal aorta in rats.The effects of JJYND on heart index(HI) and concentrations of neuroendocrine factors such as serum nitric oxide(NO),myocardium angiotensin Ⅱ(Ang Ⅱ),endothelin-1(ET-1),activities of glutathione peroxidase(GSH-Px),superoxide dismutase(SOD),concentration of myocardium hydroxyproline(Hyp),cross section area of cardiomyocyte were determined.RESULTS:
JJYND could significantly reduce the heart index,cardiomyocyte cross section area,elevate serum NO concentration,restrain myocardium Ang Ⅱ,ET-1,Hyp concentrations and improve myocardium GSH-Px、SOD activities.CONCLUSION:
Prescription JJYND has good effects on attenuating ventricular remodeling.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Traditional Patent Medicine
Year:
1992
Type:
Article
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