Effect of Herba Houttuyniae on Urinary Albumin and Insulin Resistance of Diabetes Mellitus Rats / 中药新药与临床药理

ABSTRACT

Objective To observe the effect of Herba Houttuyniae(HH) on urinary albumin and insulin resistance of diabetes mellitus(DM) rats.Methods Three rat model of diabetes mellitus was induced with streptozotocin(STZ) and high glucose-lipoids animal feeds,then treated with HH for 8 weeks.The change of biochemical parameters such as 24-h urine volume,urinary albumin,fasting insulin(FINS) level,fasting glucose and insulin sensitivity index were observed.Results After treatment,FINS level was lower in HH group than that in the model group,rosiglitazone group and losartan group(P