Formulation optimization and the in vitro release characteristics of Fuyankang Dispersible Tablets / 中成药
Chinese Traditional Patent Medicine
;
(12)1992.
Article
in Chinese
| WPRIM
| ID: wpr-577881
ABSTRACT
AIM:
To optimize the formulation of Fuyankang Dispersible Tablets and study the in vitro release characteristics of them.METHODS:
The orthogonal design was used to obtain the optimal formulation with the disintegration,hardness and weight of tablets as markers,and then dispersible uniform and the in vitro release characteristics of the optimal formulation were studied with dispersed experiment and PR-HPLC,respectively.(RESULTS:
)The proportion of each adjuvant in the optimal formulation consisted of 10% MCC,4% L-HPC,12% PVPP.The optimized dispersible tablets disintegrated in 1 min,the hardness was 5.24 kg,the average weight was 0.407 g;the dispersible uniform was excellent,and the settling velocity equation was logF=-0.028-1.001?10~(-3)t;The released rate parameters of Fuyankang Dispersible Tablets were T_(50)=3.0 min and T_d=4.0 min,which were remarkly less than that of the control group,T_(50)=14.28 min and T_d=16.62 min(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional Patent Medicine
Year:
1992
Type:
Article
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