Effect of angelica polysaccharides on adhesion molecules expressions in murine hematopoietic cells / 重庆医科大学学报

ABSTRACT

Objective:To explore the effect of angelica polysaccharide(APS)on adhesion molecules expressions in murine hematopoietic cells,in order to provide experimental evidence of APS on hematopoietic regulation and the mechanism of mobilizing.Methods:Techniques of peripheral blood white blood cell(WBC)and bone marrow mononuclear cells(MNC)count were made.Flow cytometry detected the rate of Sca-1~+ cells in peripheral blood and bone marrow and the expression of CD49d (VLA-4 of a chain),CD44 on bone marrow MNC and Sca-1~+ cells.Results:1.In APS group(4mg/kg)the number of peripheral blood WBC and Sca-1~+ cells were markedly higher than that of NS group(P