ULTRASTRUCTURAL STUDIES ON VON EBNER' GLAND OF DIABETES RATS / 解剖学报

ABSTRACT

Objective To observe the ultrastructure changes on von Ebner's gland of type 2 diabetes rats. Methods Eighteen Wistar rats were randomly divided into control group and experiment group.The diabetes rats model were induced by intraperitoneal injection streptozotocin(STZ) after high-fat food.The von Ebner's gland ultrastructure was observed under transmission electron microscope(TEM) after 8 weeks. Results Compared with the control group,in diabetes rats acinar cell nucleus appeared nucleolemma introcession and karyopycnosis;mitochondria exhibited vacuole degeneration and crista breaking;rough endoplasmic reticula expanded and showed degranulation.Conclusion A sereies of pathologic changes in von Ebner's gland of diabetes rats can be induced by diabetes,which provides morphological evidences for further investigation on the mechanism of diabetes complication.