Assessment of the Optimum LDL : HDL-cholesterol(LDL : HDL-C) Ratio for Predicting CHD / 성인간호학회지

ABSTRACT

PURPOSE: This study was aimed to determine the optimum low-density lipoprotein high-density lipoprotein-cholesterol (LDL HDL-C) ratio for predicting coronary heart disease(CHD) in Korean people. METHODS: It was analyzed this data of 5,431 adults who had undergone health examinations in a hospital in Gyeonggi-do between January 2006 and December 2007. The covariation of the coronary risk factors such as age, HbA1C, systolic blood pressure(SBP), and waist-to-stature ratio(WSR) were analyzed by using logistic regression analysis. RESULTS: The LDL HDL-C ratio in the male and female groups was mostly distributed between 1.5 and 4.0. The LDL HDL-C ratio was the most significant cholesterol-related parameter influencing CHD(male B = .306, p = .054, female B = .940, p = .010), followed by LDL-C and total cholesterol. It was observed a sharp increase in the odds ratios for LDL HDL-C ratios of 2.25 - 2.50(male) and 2.00 - 2.25(female). A significant difference was observed in both male(2.25 chi-square = 2.494, p = .072) and female(2.00 chi-square = 413.742, p = .000) groups. CONCLUSION: The risk level of CHD was set to 2.25 for males and 2.00 for females. Therefore, the optimum LDL HDL-C ratio for Koreans should be far lower than that for the people in western countries.