Implications of partial plasma coagulation factor activity in acute coronary syndrome / 国际检验医学杂志

ABSTRACT

Objective To investigate the activity of partial plasma coagulation factor activity and its clinical significance in occurrence of acute coronary syndrome(ACS). Methods The activities of co-agulation factors(FⅤ.C, FⅦC, FⅧC, FⅩC and FⅪC) were measured in 100 patients with acute myocardial infarction(AMI group) and 69 patients with unstable angina pectoris in acute stage(UAP group), the results were compared with those of 120 cases of stable angina pectoris(SAP group) and 80 healthy controls(heahhy control group). The relationship was analyzed between activities of coagu-lation factors and A MI as well as acute stage UAP. Results The patients with acute myocardial infarc-tion and unstable angina pectoris in acute phase had significantly higher plasma FⅤ.C, FⅦC, FⅧC, FⅩC and FⅪC compared with those of healthy and SAP subjects(P<0.05) ; there were no sig-nificant differences of the above activities between SAP group and healthy control group(P>0.05).Conclusion Significantly higher activation of FⅤ.C, FⅦC, FⅧC, FⅩC and FⅪC and a hyper-coagulabale state exist in acute coronary syndrome(ACS) patients in acute stage.