Analysis of medicine components from Compound Qingkailing in rat serum / 中成药
Chinese Traditional Patent Medicine
;
(12)1992.
Article
in Chinese
| WPRIM
| ID: wpr-578373
ABSTRACT
AIM:
To establish methods for identifying the antetype of Compound Qingkailing(Calculus bovis,Concha margaritifera,Radix isatidis,Cornu bubali) in rat serum by HPLC-MS~n and HPLC-TOF-MS.METHODS:
Addition of methanol to serum after Qingkailing given intravenously to rats was used to precipitate protein.The HPLC-TOF-MS provided the exact molecular weight and the HPLC-ESI-MS~n provided the m/z of multilevel fragment.The medicine antetypes were identified by combining the two methods.RESULTS:
Four main medicine antetypes in rat serum,such as geniposide,baicalein,wogonoside and cholic acid,were identified.CONCLUSION:
It is a rapid and exact method that can be used to identify other complicated traditional Chinese medicine in vivo.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional Patent Medicine
Year:
1992
Type:
Article
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