In vitro evaluation of indirubin self-emulsifying drug delivery system / 中成药
Chinese Traditional Patent Medicine
;
(12)1992.
Article
in Chinese
| WPRIM
| ID: wpr-578380
ABSTRACT
AIM:
To prepare indirubin self-emulsifying drug delivery system(SEDDS) and evaluate it in vitro.METHODS:
The criteria of SEDDS formation was studied and indirubin SEDDS preparation optimized with triangle phase diagram.In order to investigate self-emulsifying ability,the time of self-emulsifying,particle size of emulsion and the dissolution of indirubin in vitro were determined.RESULTS:
The best formulation of SEDDS was made up of labrasol-peceol-transcutol P(85∶10∶5),which served as oil phase,emulsifier and assistant emulsifier,respectively.The selected formulation could completely emulsify in 5 min and the particle size was about 100 nm.As compared with indirubin suspension,SEDDS could improve drug dissolution significantly.CONCLUSION:
SEDDS can give rise to the dissolution increase of slightly soluble drug in water in vitro.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional Patent Medicine
Year:
1992
Type:
Article
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