Espression and significance of MMP-14 and MMP-2,TIMP-2 in gastric cancer / 重庆医科大学学报

ABSTRACT

Objective:To detect the expression of MMP-14,MMP-2 and TIMP-2 in gastric ulcer tissues, gastric cancer and tissues around gastric cancer. Methods:The expression of MMP-14,MMP-2,and TIMP-2 were detected by S-P immunohistochemistry in gastric ulcer tissues,gastric cancer tissues and around tissues from operated patients of gastric cancer (n=30) and gastric ulcer patients(n=20)who were diagnosed by stomach lens. Results:(1) The expression rates of TIMP-2, MMP-2 and MMP-14was 43.3%,76.7% and 53.3% respectively in gastric cancer tissues and 56.7%,46.7% and 40%in tissues around it,but 70%,45% and 30% in gastric ulcer tissues. (2) The expression of TIMP-2 in gastric cancer was lower than that in tissues or that in gastric ulcer tissues(P0.05).The expression of TIMP-2 was negatively correlated with the expression of MMP-2 or MMP-14(rs=-1.0,P