Pharmacokinetics of sinomenine in rabbits / 重庆医科大学学报

ABSTRACT

Objective:To establish a HPLC method for measurement of serum concentration of sinomemine in rabbits and explore it’s pharmacokinetics. Methods:6 rabbits were intragastricly administrated sinomenine with the dosage of 45mg/kg,2 ml blood were collected at 0.25h、0.5h、1.0h、1.5h、2.0h、3.0h、4.0h、6.0h、8.0h、10.0h and 12.0h after oral administration.concentrations of drug were determined by HPLC,datas were calculated with 3P97 software and pharmacokinetics was explored. Results:T1/2(Ka) was(0.31?0.26)h,T1/2(Ke) was(3.15?0.82)h,Tmax was(1.05?0.53)h,Cmax was(15.09?4.15)?g/ml,AUC0→∞ was(84.27?13.02)(?g?h)/L,AUC0→T was(78.29?13.46)(?g?h)/L. Conclusion:absorption and elimination of Sinomenine were quickly and Tmax is short,concentration of drug is high in rabbits after intragastric administration.