Observance on the expressions of spasmolytic polypeptide(SP) and intestinal trefoil factors(ITF) of gastric mucosa affected by Jianweiyuyang(JWYY) pills and study of the potential mechanisim of JWYY against the recurrence of peptic ulcer / 重庆医科大学学报

ABSTRACT

Objective:To observe the effects of Jianweiyuyang(JWYY) pills on expressions of spasmolytic Polypeptide(SP)and intestinal trefoil factors(ITF) and analyze its potential mechanism. Methods:A Total of 76 gastric ulcer patients(final diagnosis by gastroscope),were randomly divided into two groups,JWYY treatment group,(36 cases,treatment group) and Ranitidine control group(36 samples,control group).Among them 50 Hp-positive PU patients were confirmed by gastroscope,histological inspection, and urease test,and showed the differentiation of symptoms and signs of the traditional Chinese medicine is the stagnation of liver-QI with deficiency of the spleen type for these 50 patients. There were 12 case in Normal groups.Detection on Biospy Specimens of gastric mucosa was done.The change of SP expression was detected by immunohischemicity,ITF by Western blotting and the contents of aninohexose and phosphatide in ulcerated gastric mucosa were measured. Results:The contents of aninohexose and phosphatide of PU patients increased in JWYY group and there was significant difference between JWYY group and Ranitidine group(P